CBD oil effects in humans
CBD works – no matter whether in the form of oil, drops, liquid or other. That much is certain, but the effect has not yet been fully researched. Although this is a pity, the very positive response from the scientific community to date gives reason to hope for positive effects. The mechanism of action of cannabidiol is already described in the literature and this is exactly what we are looking at today. In addition, we will tell you what the CBD effect could be helpful according to the current status.
Cannabidiol and the pleiotropic effect
Pleiotropic – what a word. When it is said that CBD is a pleiotropic substance, it simply means that the effect and side effect come about in many different ways. Of course, this does not make it easier for researchers to find out the exact mechanisms of action.
What is certain, however, is that CBD is not psychoactive in comparison to THC and thus does not cause any changes in consciousness. In the classical sense, the cannabidiol effect has nothing to do with the state of intoxication THC is capable of triggering. Furthermore, the CBD Oil effects also promise multiple therapeutic benefits.
CBD oil effects on different receptors
What is certain is that cannabidiol interacts with different receptors – either actively or simply blocking them. In addition to the “classic” cannabinoid receptors (CB1 and CB2) on which THC has its effect, CBD has a relatively low binding affinity. Nevertheless, CB1 in particular plays a not insignificant role.
- CBD counteracts THC administered simultaneously on CB1 and inhibits its side effects (e.g. cravings & anxiety).
- In addition, CBD can also act actively on this receptor by…
- … CBD inhibits the FAAH enzyme and thus increases the anandamide concentration in the body.
- Anandamide is an endogenous substance that has a high affinity to the CB1 receptor.
- On CB2 cannabidiol has an effect on the nerve and immune system by also boosting the concentration of the 2-AG enzyme.
Effect on TRPV-1, a vanilloid receptor
Vanilloid receptor. Reminiscent of vanilla – also has to do with it. The receptor on which our CBD effect also develops was actually named after the vanilla pod. Just like the pod, cannabidiol stimulates this receptor and thus acts on…
- … body temperature,
- Inflammations and
- Pain perception.
In particular the CBD effect in headaches can be explained by it, because the vanilla pod was estimated in earlier times due to just this effect against this kind of pain.
Cannabidiol acts directly on the serotonin receptor
Serotonin receptors are a powerful instrument in our body that knows how to play cannabidiol. Actually, it stimulates the 5-HT1A receptor belonging to this group. The result is a broadside of positive CBD effects:
- Stimulates sleep
- sensation of pain
- Against nausea & vomiting
- hunger control
- Influencing the addictive behaviour
Through this cascade of effects, CBD seems to be a potential helper in opiate withdrawal, in the treatment of post-traumatic stress disorder or in diseases such as Parkinson’s disease.
Anxiolytic effect by activation of P1 receptors
P1 or andenosine receptors regulate the cardiovascular system and release anti-inflammatory substances in the body. By activating these receptors, cannabidiol can also have a positive effect in this respect.
In 2012, Ribeiro et al. showed in an in Vivo study that CBD can reduce inflammation of an injured lung in rats by activating the andenosine A2A receptor. Another study observed a similar effect of CBD and showed that it is able to reduce pro-inflammatory messenger substances (Malfait et al. 2000).
Apart from this, andenosine receptors play a key role in the brain by blocking substances such as dopamine, glutamate, norepinephrine and acetylcholine. Thus, the CBD effect is able to intervene in this cycle of stimulating neurotransmitters.
Antagonistic effect on the GPR55 receptor
In the course of the cannabidiol effect, so-called GPR55 receptors can be switched off. These atypical cannabinoid receptors regulate, for example, the reabsorption of nutrients from bones into the bloodstream. The CBD can stop this effect, which could lead to increased bone stability.
According to current investigations by Chinese researchers, the growth of cancer cells could also be inhibited by the antagonistic effect of CBD on these receptors (G Hu et al. 2010).
There are isolated indications that the CBD Oil effects at the GPR55 receptor can also cause anti-inflammatory effects.
Peroxisome proliferator-activated receptors
These receptors are located in the nucleus and are divided into three subclasses:
- PPAR alpha
- PPAR beta
- PPAR gamma
According to research, cannabidiol affects both the alpha and the gamma receptors by acting as an agonist, i.e. activator. This can inhibit the growth of tumour cells and also lead to a reduction in beta-amyloid proteins. These proteins play a role in the development of Alzheimer’s disease, which reveals another positive CBD effect. (Esposito et al. 2011)
PPAR receptors also play a role in the development of diabetes (insulin intensity!) and PPAR-alpha in particular influences mental illnesses such as schizophrenia. In both cases, patients could benefit massively from the CBD Oil effects.
Possible CBD oil effects at a glance
Even if the cannabidiol effect is not yet completely transparent, the current state of knowledge allows conclusions to be drawn about possible areas of application. Diseases and conditions in which CBD could have an effect include:
- skin disorders
- drug addiction
- Amyotrophic lateral sclerosis
- Multiple Sclerosis
- Dementia/Alzheimer’s disease
- anxiety states
- Pathological stress
- Bipolar disorder
- Crohn’s disease
- cardiovascular disorders
- digestion problems
- motion sickness
- excess of weight
- compulsion neuroses
- Parkinson’s disease
- MAD COW DISEASE
- Post-traumatic stress disorder
- sickle cell anemia
- sleep disturbances
Below you will find a list of the mechanisms of action attributed to cannabidiol:
- Analgesic (analgesic)
- Anti-inflammatory (against inflammation)
- Anorexic (appetite suppressing)
- Antiemetic (against nausea & vomiting)
- Anti-kinetic (soothing)
- Anxiolytic (Anxiolytic)
- Neuroleptic (Against disorders of consciousness)
- Antiepileptic (against epilepsy)
- Antispasmodic (antispasmodic)
- Vasolizing (vasodilative)
- Antiinsomnia (calming, sleep-inducing)
- Immunosuppressive (against allergies/autoimmune diseases)
- Antidiabetic (against symptoms of diabetes)
- Neuroprotective (nerve protecting, against Alzheimer & Co.)
- Antipsoriatic (Against psoriasis & skin problems)
- Antiischemic (stimulates blood circulation)
- Antibacterial (Against bacteria)
- Antifungal (against fungal infections)
- Antiproliferative (inhibits tumor growth)
How you benefit from the CBD oil effects
Since cannabidiol is freely available for sale, anyone can benefit from it. We prefer CBD oil because it is cheaper than other types (chewing gum, spray, capsules) and can be dosed precisely.
To determine the appropriate amount to take, it takes a lot of trial and error. There are strong individual differences in effectiveness, therefore it is important to find the personal “sweet spot”.